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1994-10-25
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Document 2640
DOCN M94A2640
TI Parotid swelling in children with HIV infection.
DT 9412
AU Tucci F; Castelli G; Bottero S; Scaccia S; Livadiotti S; Bernardi S;
Krzysztofiak A; Mattia S; Elia L; Bambino Gesu Children Hospital, Rome,
Italy.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):258 (abstract no. PB0462). Unique
Identifier : AIDSLINE ICA10/94369935
AB OBJECTIVE: To investigate clinical, immunological and imaging features
of parotid enlargement in children infected with HIV. MATERIALS: 22
patients were studied (12 M and 10 F) out of 90 HIV infected children
between 17 months and 14 years old, with evidence of chronic parotid
gland swelling (8 vertically infected and 2 by blood transfusion) and
followed for a mean period of 20 mths. At entry nobody fulfilled the CDC
AIDS definition but 6 patients presented LIP. All the children were
studied with echography; 7 patients were also studied with sialo-TC.
RESULTS: Almost all the children had bilateral parotid swelling which
appeared at a mean age of 4 years (range 17-80 mm) in the vertically
infected and after 6 years from the infection in the two transfused.
Pulmonary lymphoid hyperplasia was revealed in 6 patients. CD4/CD8 ratio
was reversed in all the children (mean 0.47). Sonographic images showed
small diffused hypoechoic areas in all patients and in 4 large anechoic
areas almost totally replacing gland. Follow-up clinical examinations of
patients showed a slow evolution in 5 cases, spontaneous regression in 1
and recurrent infections with suppuration in 3. Superficial monolateral
and bilateral parotidectomy was performed in these cases and in one of
the histological diagnoses of B cell lymphoma occurred. This child is
still well after 2 years. CONCLUSIONS: Parotid swelling seems to be
associated with milder clinical courses but in patients with evidence of
large cystic areas a surgical approach to prevent recurrent infection or
neoplasm could be indicated.
DE Adolescence AIDS-Related Opportunistic
Infections/ETIOLOGY/*ULTRASONOGRAPHY Child Child, Preschool Female
Follow-Up Studies Human Hyperplasia HIV
Infections/TRANSMISSION/*ULTRASONOGRAPHY Infant Italy Lymphoma,
AIDS-Related/SURGERY/ULTRASONOGRAPHY Male Parotid
Diseases/ETIOLOGY/*ULTRASONOGRAPHY Parotid
Gland/PATHOLOGY/ULTRASONOGRAPHY Parotid
Neoplasms/SURGERY/ULTRASONOGRAPHY Parotitis/ETIOLOGY/*ULTRASONOGRAPHY
MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).